Not always possible as negative cultures doesn’t necessarily mean absence of infection. Significant numbers of microbial species are not culturable. Something that is also important to mention is that antibiotic research is inherently unprofitable for pharmaceutical companies. They’re spending copious amounts of money to develop a drug that will purposefully be used as little as possible and for as short a duration as possible. Compare that to the very profitable monoclonal antibody drugs for cancer and inflammatory conditions. Plague Doctor Mask Class of 2021 T-Shirt Often extended courses of treatment (sometimes lifelong) which quickly produce return on investment. Just a warning though (not criticism!), this post is really dense and I think a lot of people are going to skip it because of the length.
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Everything here is great information, but I think you could reach a larger audience by cutting out the bits that aren’t 100% essential and breaking it into smaller sections that can each be summarized with a single sentence. Unheard diseases and antibiotic resistance are both very scary topics. I can only hope that this current pandemic proved us that burying our heads in sand as a response to such fears isn’t an actual solution. Plague Doctor Mask Class of 2021 T-Shirt Thanks! I do hope that this pandemic serves as a wake up call, so that in the future we can have a better response that prevents the death and suffering we have observed this time around. Sorry! I just realized I never followed through on this. Would you like the blue “Louis Pasteur” text with the John Mill image?
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I think a lot of poor antimicrobial stewardship is driven by the increasingly corporate, metric-based style of medicine practiced in the US. It’s very unsatisfying to patients to go to the primary care for a mild sinusitis or respiratory infection and be told that there’s not much that can be done other than symptom relief–and unsatisfactory reviews are a result. Plague Doctor Mask Class of 2021 T-Shirt Additionally, higher standards should be required for the prescription of antibiotics, to increase accountability of physicians; these standards could involve clinically verifying the presence of susceptible bacteria prior to administering a drug in situations where the disease in not life-threatening.